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For some agents such as venlafaxine, benefit may continue to increase more modestly at higher doses, while adverse-effect discontinuation also increases

J Neurogastroenterol Motil, 20(1): 31-40 Abell, et al

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Previous studies with the antibiotic sulfamethoxazole have shown that oxidative stress can potentiate the formation of protein adducts in cells (Lavergne et al., 2009)

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